Must Reads
Sattarnezhad N*, Kockum I*, Thomas OG, Liu Y, Ho PP, Barrett AK, Comanescu AI, Wijeratne TU, Utz PJ, Alfredsson L, Steinman L, Robinson WH, Olsson T*, Lanz TV*. Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls. Proc Natl Acad Sci U S A. 2025 Mar 18;122(11):e2424986122. doi: 10.1073/pnas.2424986122. Epub 2025 Mar 10. PMCID: PMC11929495.
In a large international cohort of MS patients and population controls, we show that antibodies against EBV EBNA1 and its human molecular mimics convey significantly increased risk for MS, and genetic risk factors synergistically add additional risk.
Robinson WH, Younis S, Love ZZ, Steinman L, Lanz TV. Epstein-Barr virus as a potentiator of autoimmune diseases. Nat Rev Rheumatol. 2024 Nov;20(11):729-740. doi: 10.1038/s41584-024-01167-9. Epub 2024 Oct 10. PMID: 39390260.
We review how Epstein Barr virus (EBV) causes and contributes to autoimmune diseases.
Lanz TV, Brewer RC, Ho PP, Moon JS, Jude KM, Fernandez D, Fernandes RA, Gomez AM, Nadj GS, Bartley CM, Schubert RD, Hawes IA, Vazquez SE, Iyer M, Zuchero JB, Teegen B, Dunn JE, Lock CB, Kipp LB, Cotham VC, Ueberheide BM, Aftab BT, Anderson MS, DeRisi JL, Wilson MR, Bashford-Rogers RJM, Platten M, Garcia KC, Steinman L, Robinson WH. Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. Nature. 2022 Mar;603(7900):321-327. doi: 10.1038/s41586-022-04432-7. PMCID: PMC9382663.
We analyze the single cell B cell repertoire in cerebro-spinal fluid and blood of patients with multiple sclerosis (MS) and demonstrate that Epstein-Bar virus (EBV) contributes to MS via molecular mimicry.
Brewer RC, Ramadoss NS, Lahey LJ, Jahanbani S, Robinson WH*, Lanz TV*. BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2. Nat Immunol. 2022 Jan;23(1):33-39. doi: 10.1038/s41590-021-01088-9. Epub 2021 Nov 30. PMCID: PMC8776031.
We discern the acute B cell response to RBD and S2 protein in SARS-CoV-2 vaccinated individuals, using single-cell RNA sequencing, single-cell B cell repertoire sequencing, and analyses of human-derived monoclonal antibodies.
Murphy KA, Bhamidipati K, Rubin SJS, Kipp L, Robinson WH*, Lanz TV*. Immunomodulatory receptors are differentially expressed in B and T cell subsets relevant to autoimmune disease. Clin Immunol. 2019, 209:108276. doi:10.1016/j.clim.2019.108276. PMID: 31669582 (*co-senior and co-corresponding)
We investigate expression levels of immunomodulatory receptors in B and T cells in autoimmune disease using high-parameter flow cytometry.